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Take 5 with Happy mcgarrybowen CEO Kartik Iyer
Source:  The Financial Express
Friday, 17 August 2018 01:53

Sapiens is the current book am reading. Love it! I have a lot of books on my bookshelf that I have bought and I am yet to read. I guess I am a long way from Mein Kampf by Adolf Hitler, says Happy mcgarrybowen CEO Kartik Iyer.

Researchers are developing vaccines for human parasites
Source:  Udaipur Kiran
Friday, 17 August 2018 01:53

Helminthic parasites, like hookworm and liver flukes (schistosomiasis), affect an estimated 1 billion people worldwide. Infection from hookworm and schistosomiasis result in a combined loss of as much as 92 million disability-adjusted life years annually. Little progress has been made to relieve this global burden and eradicate these parasites until now.

A partnership between the George Washington University (GW) School of Medicine and Health Sciences and the Texas Children’s Hospital Center for Vaccine Development has led to development of several hookworm and schistosomiasis vaccine candidates. A paper published in Trends in Parasitology outlines lessons learned along this critical path.

“It is more critical now, than ever, to address questions around helminth vaccine development,” said Jeffrey M. Bethony, PhD, professor of microbiology, immunology, and tropical medicine at the GW School of Medicine and Health Sciences. “Due to our unique partnership and leadership in this area, we are in a position to offer guidance to those researchers looking to help make progress in eradicating these diseases of poverty.”

For almost two decades, this partnership has worked to identify, produce, and test recombinant protein-based vaccines against human hookworm and schistosomiasis. The lengthy critical path includes five stages: pre-clinical development; process development; production according to current good manufacturing practice; pre-clinical safety and toxicity testing; and clinical trials conducted in compliance with current good clinical practice. Each stage meets criteria included within the investigational new drug application that is submitted to the regulatory bodies of the United States, Europe, and Brazil.

The paper outlines the following five lessons learned:

1. Avoid the immunoglobulin E (IgE) trap. One of the first recombinant larval helminth vaccines tested in humans was the 21.3 kDa N. americanus Ancylostoma Secreted Protein-2 (Na-ASP-2). Allergic reactions in a small group of study participants led to the conclusion that Na-ASP-2 may interact with IgE antibodies induced by previous hookworm infection in individuals living in endemic areas, triggering this response. This halted development, leading to different vaccine targets and a revised critical path.

2. Allow for ample time and resources during process development and manufacturing of helminth vaccines, with a focus on ability to scale-up to industrial-level manufacturing.

3. Develop vaccine potency assays that do not rely on the traditional immunization-challenge potency model (as used for vaccines against pertussis, diphtheria, and rabies) as neither helminth pathogen induce reliable mortality in an animal model nor do these vaccines induce sterilizing protection.

4. Overcome the ‘deficient acquired immunity’ that occurs during chronic helminth infection, in order to attain sufficient vaccine immunogenicity in these individuals.

5. Accelerate vaccine efficacy testing in humans through use of controlled human infection models as currently established at GW for controlled human hookworm infection.

“Creating a helminth vaccine is arduous. There are challenges at all stages, and at many points, we were responsible for creating novel testing, formulation, and manufacturing processes, in order to advance to the next step in our clinical trials,” said David Diemert, MD, associate professor of medicine at the GW School of Medicine and Health Sciences. “We hope this paper will help accelerate activities for other researchers as they progress along this critical path.”

Story Source:

Materials provided by George Washington University. Note: Content may be edited for style and length.

source : sciencedaily.com


Human wastewater valuable to global agriculture, economics
Source:  Udaipur Kiran
Friday, 17 August 2018 01:52

It may seem off-putting to some, but human waste is full of nutrients that can be recycled into valuable products that could promote agricultural sustainability and better economic independence for some developing countries.

Cities produce and must manage huge quantities of wastewater. Researchers at the University of Illinois at Urbana-Champaign have developed a model to clarify what parts of the world may benefit most from re-circulation of human-waste-derived nitrogen, potassium and phosphorus from cities and back into farm fields. They report their findings in the journal Nature Sustainability.

“We grow our crops in the field, apply nutrient-rich fertilizers, eat the crops, excrete all of the nitrogen, phosphorus and potassium and then those nutrients end up at the wastewater treatment plant,” said Jeremy Guest, a civil and environmental engineering professor and study co-author. “It is a very linear, one-directional flow of resources. Engineering a more circular nutrient cycle would create opportunities that could benefit the environment, economy and agriculture.”

The team’s exploratory exercise examined 56 of the largest cities across six continents to assess the feasibility of human-waste-derived nutrient recirculation. They looked at factors like transport distance, population and cropland density, crop nutrient requirements and what types of products would do best where.

“In some cases, wastewater that has been treated for safety can be used to simultaneously irrigate and fertilize crops,” said John Trimmer, an Illinois graduate student and lead author on the study.

Treated wastewater is an option for places where crops grow close to cities, such as many parts of Africa, Asia and Europe. However, water is challenging to transport because of its weight and relatively low nutrient content, so it is not a good option when nutrients must travel longer distances to reach farmland, the researchers said.

“In some cities, we would need to use more advanced technology to recover a more concentrated product suitable for longer transport distances,” Guest said. “These are similar to the crystalized fertilizers that we are accustomed to and, in most cases, the technology to produce these from human waste is well established.”

The study shows that a variety of cities throughout the world could benefit from this proposed sustainability approach — not only for helping grow crops, but also for their economic independence.

“We found, for example, that in Cairo, Egypt, if all of the nitrogen resources from wastewater were utilized, the city could cut Egypt’s nitrogen fertilizer imports by roughly half,” Trimmer said. “This type of approach could also help smallholder farmers in places like Sub-Saharan Africa gain better access to fertilizer than what is currently available.”

The study also identifies parts of the world where nutrient recirculation may have less impact.

“Most of the population centers we looked at throughout the U.S. don’t appear to be the best candidates,” Trimmer said. “For example, places like New York and Boston are too far from intense agriculture areas. However, the Midwest — Chicago in particular — did a bit better in our analysis.”

The team acknowledges that there are limitations to this type of exercise.

“Because this was developed as a global analysis, the method does not allow us to examine specifics for each city, like the driving routes to haul nutrients or locations of wastewater plants, among other details,” Guest said. “The results of this exercise should be taken as estimates of nutrient transport distances and are useful for identifying broad trends and locations that may warrant further investigation into reuse strategies.”

source : sciencedaily.com


Have Been Told Governance Is For Government, Not For Courts: Top Court
Source:  NDTV News
Friday, 17 August 2018 01:52

The Supreme Court on Thursday expressed its limitation in passing coercive orders for alleged failure by some states to set up panels on the issue of urban homelessness, saying its "whip has broken"...

शर्मनाक: मासूम बच्ची साथ बलात्कार की घटना ने सबको झकझोर के रख दिया
Source:  UdaipurTimes
Friday, 17 August 2018 01:52

उदयपुर जिले के सलूम्बर थाना क्षेत्र के गांव में बुधवार को बेहद शर्मनाक हादसा पेश आया। जहाँ एक ओर देश स्वतंत्रता दिवस के जश्न में देश डूबा हुआ था वही दूसरी तरफ एक हैवान मासूम बच्ची की अस्मत तार तार कर रहा था। जहाँ स्वतंत्रता दिवस पर ‘बेटी बचाओ’ पर नाटक का मंचन हुआ, वहीँ दोपहर बाद एक मासूम बच्ची के साथ बलात्कार की घटना ने सबको झकझोर के रख दिया।

प्राप्त जानकारी के अनुसार एक 10 वर्षीया मासूम बालिका जंगल में बकरियां चराने गई थी तभी दोपहर करीब दो बजे मुंह पर रुमाल बांध कर एक दरिंदा मासूम के पास आया और उसके पिताजी से पहचान बताकर और बच्ची को बहला फुसला कर जंगल में ले जाकर उसके साथ बलात्कार किया। आवाज़ करने पर उस हैवान ने बच्ची के मुंह पर कपडा बांध दिया और बाद में वहां से भाग निकला। रोती बिलखती बच्ची ने घर पर आकर आपबीती सुनाई तो लहूलुहान बच्ची को परिजन गींगला सामुदायिक स्वाथ्य केंद्र ले गए। जहाँ मासूम की नाज़ुक हालत को देखते हुए सलूम्बर रेफर किया जहाँ से प्रारम्भिक उपचार के बाद उदयपुर रेफर किया गया। बच्ची की हालत नाज़ुक बताई जा रही है।

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सलूम्बर पुलिस वृत्ताधिकारी शैलेन्द्र सिंह ने पहुंचकर बच्ची और परिजन से घटना की जानकारी ली। सलूंबर के गांवडा पाल पुलिस चौकी समेत गींगला थाना पुलिस ने आसपास के जंगलो में सघन तलाशी अभियान छेड़ दिया है। पुलिस बच्ची के बताये हुलिए के अनुसार अपराधी की तलाश में जुट गई है। पुलिस तलाशी में डॉग स्क्वाड की मदद ले रही है। घटना को लेकर ग्रामीणों में जबरदस्त रोष फैला हुआ है।

उधर घटना पर राज्य बाल अधिकार संरक्षण आयोग की अध्यक्ष मनन चतुर्वेदी ने संज्ञान लेकर मामले की सम्पूर्ण रिपोर्ट आयोग को भेजने सहित बालिका के स्वास्थ्य एवं मुलजिम की जल्द गिरफ़्तारी के आदेश जिला पुलिस अधीक्षक को दिए। चतुर्वेदी ने घटना को दुखद बताते हुए मामले को गंभीरता से लिया है। पीड़िता के परिजनों को नियमानुसार दी जाने वाली सहयता मुहैया करवाने के निर्देश भी अधिकारियो को दिए है।

The post शर्मनाक: मासूम बच्ची साथ बलात्कार की घटना ने सबको झकझोर के रख दिया appeared first on UdaipurTimes.com.


Last rites of Vajpayee to be performed at 5 pm today, govt declares 7 day mourning
Source:  Oneindia News
Friday, 17 August 2018 01:51

New Delhi, Aug 16: The government has announced a 7 day mourning from August 16 to 22 after the passing away of former prime minister and Bharat Ratna, Atal Bihari Vajpayee. The flag will fly at half mast and Vajpayee

Industrial areas on Periyar banks inundated
Source:  The Hindu
Friday, 17 August 2018 01:51

Products and raw materials shifted to safer places

Odisha to showcase its biodiversity
Source:  The Hindu
Friday, 17 August 2018 01:51

World-class interpretation centre to come up at Dangamal near Bhitarkanika Park

When Vajpayee met journalists for the last time
Source:  The Hindu
Friday, 17 August 2018 01:49

Ill-health forced an unexpected exit of party stalwart from the political stage.

Vajpayee was conferred Bangladesh Liberation War Honour by the country
Source:  Oneindia News
Friday, 17 August 2018 01:49

New Delhi, Aug 16: Former Prime Minister Atal Bihari Vajpayee was not only popular in India but was also admired in the neighbouring countries. Despite animosity with Pakistan, he was popular among people of Pakistan. Similarly he was so popular in Bangladesh

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